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What is CBN (Cannabinol) and its Medical Benefits.
CBN like many cannabinoids, is known as a “Phytocannabinoid”. Produced naturally by the cannabis plants, with a similar structure to that of THC. Phytocannabinoids interact with the bodies natural Endocannabinoid System (ECS).
The two most popular chemical compounds of cannabis are CBD and THC. There is new research coming out that various other chemical compounds extracted from cannabis can have unique medical and therapeutic effects. Let’s dive into CBN and how it can have medical applications.
Note:The information given on this page is not medical advice and should be taken in conjunction with medical professional advice. Individuals wanting medical advice on this issue should consult their local healthcare professionals.
What Is Cannabinol (CBN)?
CBN or Cannabinol like many cannabinoids, is known as a “Phytocannabinoid”. Produced naturally by the cannabis plants, with a similar structure to that of THC. Phytocannabinoids interact with the bodies natural Endocannabinoid System (ECS). The Endocannabinoid System is neural system found in the body believed to be involved with returning the human body to a balanced state. Processes, such as fertility, appetite, mood, pain, and memory formation can all be altered by this system (Read More). Therefore the cascading effect after a cannabinoid binds
The Potential Medical benefits of CBN
Most of the medical benefits of CBN are in its immune-related effects, sedative/sleep aid qualities and pain relief properties. Research on autoimmune disorders such as Chron’s disease and Ruminator Arthritis are looking positive for CBN. here is a list of all the known medical effects of CBN.
Conditions for which CBN is particularly effective in providing symptom relief:
CBN acts on cannabinoid receptors 1 and 2 (CB1 & CB2). As a partial agonist, the CBN molecule does not fit ‘perfectly’ (rather partially) into the CB1 or CB2 receptor. In contrast, Anandamide an agonist that causes the ‘Runners High’ is a full agonist meaning the molecules fit like a key to a lock. Being an agonist to the CB1 Receptor means that CBN causes a ‘mild’ psychoactive effects (Similar to THC). However, unlike THC, CBN has a higher affinity for the CB2 receptor compared to the CB1, making the psychoactive effects a lot milder. Because of this high affinity for the CB2 receptor, CBN interacts largely with the immune system. However, CBN does still interact with the CB1 receptor, causing both pain suppression and appetite stimulation.
The CBN molecule may also aid in therapeutic application in diseases such as obesity. In a disease like obesity, CB1 cannabinoid receptors are up-regulated. the CB1 receptor has been shown to cause weight loss and other health benefits (Read More). Micodosages of CBN could lead to a down-regulation of receptors in both CB1 & CB2 as a result of supplemental tolerance.
Where Does CBN come from?
Cannabinol or CBN is mainly found in the aged Trichomes of The Cannabis Flower.(Read More). The THC molecules in the Trichomes Breakdown into CBN, largely due to exposure to heat, light and time. Therefore as CBN content increases, THC content will decrease in aging flower bud.
Note Figure 1. Shows Cannabigerolic Acid (CBGA) is the main precursor of the cannabinoids CBN & CBD.
When Was CBN Found?
In 1896 Wood and colleagues in Cambridge Isolated the first CBN cannabinoid, at the time this represented the first natural cannabinoid to be obtained in pure form.
King and colleagues in 1940, correctly determined the structure of CBN, and incorrectly assumed it to be the active psychotropic ingredient of Cannabis. This confusion was largely due to the CBN, being derived from the ageing of the THC molecule when exposed to light, heat and time.
Is CBN Legal in Australia?
Yes : For prescription use only or trace amounts in skin/food products.
The Narcotic Drugs Amendment Act of 2016 came into effect and allowing some states to have general practitioners and/or specialist to prescribe medicinal marijuana to patients. However, nation wide exception to this rule is the requirement for special approval for children under 16 and patients with a history of drug abuse.
Where can you get medical cannabis treatment by state:
The cannabis doctors Australia CDA offers both affordable medicinal cannabis and also treatment plans for specific health needs. The CDA does not take payment for products. The CDA doctor prescribes legal medical cannabis products on the market. The doctor will work with the patient in the consultation room. The CDA will then help find the most suitable strain and dosage schedule for their clients needs. All their products grown from natural cannabis in pharmaceutical grade (GMP) sites. Doctors of CDA work with their patients to make help with an applications to the Department of Health.
Initial consultation - $200
Follow-up appointment -$65
Additional application are $35 per product.
Do Healthcare Funds Support Cannabis Products?
Yes - A patients healthcare funds can support a portion of the consultations and hemp/cannabis product. The level of cover is a contributing factor.
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